It depends on the job and the company. Since most recruiters filter your resume through a database of some kind, and output the same thing for all candidates, the formatting is usually rarely seen by the hiring manager in my experience - putting your resume on fancy paper or doing layout tricks is generally a waste of time. Now, if it is a job at an ad agency or something, maybe.

The content of the resume is more important than the layout. Arial 12 pt is fine. And I'm a graphic designer.