If you can do all that you need, then I say give it a go!

You can always have a dual-boot system for those one or two bothersome applications that you just can't find good replacements for (like Coreldraw in my case).

I'll tell you one thing though; with my new digital SLR camera and digiKam in Linux my workflow and sorting of photos is so much better than it has been in any other OS I've used! I'm quite stoked about it.